Product Name :
20-carboxy Arachidonic Acid (CAS 79551-84-1)
Synonym :
20-carboxy AA
Application :
20-carboxy Arachidonic Acid is a PPARα and PPARγ activator
CAS:
79551-84-1
Purity:
Molecular Weight:
334.45
Formula :
C20H30O4
Physical state:
Liquid
solubility :
Shipping Condition :
Store at -20° C
Melting point:
SMILES:
C(CCC(=O)O)C/C=C\\C/C=C\\C/C=C\\C/C=C\\CCCC(=O)O
References:
:16(R)-hydroxy-5,8,11,14-eicosatetraenoic acid, a new arachidonate metabolite in human polymorphonuclear leukocytes.17288-36-7 manufacturer | Bednar, MM.5-Bromo-1,3-thiazole-2-carbaldehyde custom synthesis , et al. 2000. Biochem Pharmacol. 60: 447-55. PMID: 1085644120-hydroxyeicosatetraenoic acid (20-HETE) metabolism in coronary endothelial cells. | Kaduce, TL., et al. 2004. J Biol Chem. 279: 2648-56. PMID: 1461245120-carboxy-arachidonic acid is a dual activator of peroxisome proliferator-activated receptors alpha and gamma. | Fang, X., et al. 2007. Prostaglandins Other Lipid Mediat. 82: 175-84. PMID: 17164145Degradation of very long chain dicarboxylic polyunsaturated fatty acids in mouse hepatocytes, a peroxisomal process. | Nguyen, SD., et al. 2008. Biochim Biophys Acta. 1781: 400-5. PMID: 1861955620-HETE and blood pressure regulation: clinical implications.PMID:33491578 | Wu, CC., et al. 2014. Cardiol Rev. 22: 1-12. PMID: 23584425Polyunsaturated fatty acid metabolites as novel lipidomic biomarkers for noninvasive diagnosis of nonalcoholic steatohepatitis. | Loomba, R., et al. 2015. J Lipid Res. 56: 185-92. PMID: 25404585Ethanol at low concentrations protects glomerular podocytes through alcohol dehydrogenase and 20-HETE. | McCarthy, ET., et al. 2015. Prostaglandins Other Lipid Mediat. 116-117: 88-98. PMID: 25447342Cytochrome P450 omega -Hydroxylases in Inflammation and Cancer. | Johnson, AL., et al. 2015. Adv Pharmacol. 74: 223-62. PMID: 26233909The role of 20-HETE in cardiovascular diseases and its risk factors. | Waldman, M., et al. 2016. Prostaglandins Other Lipid Mediat. 125: 108-17. PMID: 27287720Arachidonic Acid Metabolite as a Novel Therapeutic Target in Breast Cancer Metastasis. | Borin, TF., et al. 2017. Int J Mol Sci. 18: PMID: 29292756Arachidonic Acid Metabolism and Kidney Inflammation. | Wang, T., et al. 2019. Int J Mol Sci. 20: PMID: 31357612Eicosanoid Profiles in the Vitreous Humor of Patients with Proliferative Diabetic Retinopathy. | Lin, AL., et al. 2020. Int J Mol Sci. 21: PMID: 33050335Targeted fatty acid metabolomics to discover Parkinson′s disease associated metabolic alteration. | Zhang, J., et al. 2021. J Mass Spectrom. 56: e4781. PMID: 34523199Altered renal P-450 metabolism of arachidonic acid in Dahl salt-sensitive rats. | Ma, YH., et al. 1994. Am J Physiol. 267: R579-89. PMID: 8067471The role of the cytochrome P450-dependent metabolites of arachidonic acid in blood pressure regulation and renal function: a review. | Rahman, M., et al. 1997. Am J Hypertens. 10: 356-65. PMID: 9056695